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Our lab is interested in the molecular mechanisms that lead to advanced prostate cancer. We have projects that use pure protein, cultured cells, and mouse models to study these mechanisms. | How does hyaluronan matrix synthesis and remodeling promote progression?Hyaluronan (HA) is a glycosaminoglycan not normally found in the prostate, but very abundant in advanced stage prostate tumors. HA can be secreted by tumor cells ... |
 | How do tumor cells lose their dependence on circulating hormones?When prostate tumors are advanced, men are often treated with androgen deprivation therapy. Tumors initially respond by regressing but inevitably recur, ... |
 | How can we monitor the course of tumor growth and metastasis in living animals and what can it tell us about cancer?We are working to optimize fluorescent molecular detection of tumor cells in living mice. We use a near-infrared fluorophore (i.e.; LI-COR IRDye 800CW) coupled to a ... |
